Платиновые препараты

Platinum-based anticancer drugs

Amongst the most frequently prescribed anticancer drugs are those based on platinum, such as cisplatin, carboplatin and oxaliplatin. Platinum-based complexes are important drugs for the treatment of cancer diseases.
The platinum-based compound known for the longest time (since 1864) is Peyron’s chloride, today used under the name of cisplatin. As a chemotherapeutic drug it has been used for cancer treatment since 1978. However, its use is limited due to two drawbacks, namely side effects (nephrotoxicity, ototoxicity, vomiting) and resistance, which is either primary (intrinsic) or secondary (acquired). Since no effective and safe anticancer therapy has so far been available, current research is aimed at developing new drugs or improving those used at present.
Well-known research techniques are available in medicine and pharmaceuticals, but few data are available for research by other methods. The purposes of this study is to receive more information about the mechanism of interaction of molecules of the platinum anticancer drug with saline, using the methods of spectroscopy.

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